Jerry Brown, California Democrats appear to be big winners in election

Gov. Jerry Brown’s $6-billion-a-year tax initiative to rescue California schools and the state's finances appeared to squeak by with a victory early Wednesday, and Democrats' grip on Sacramento tightened as the party crept toward winning a super-majority in both houses of the Legislature.

Tuesday's election also brought an end to the three-decade-long congressional career of Rep. Howard Berman, who early Wednesday morning conceded defeat in his political slugfest against fellow Democrat Brad Sherman in the San Fernando Valley.

The bitter contest between Sherman and Berman, awash in more than $13 million in campaign spending by the candidates and independent political groups, was triggered when California's newly drawn political boundaries put the two incumbents in the same district.

"I congratulate Brad. ... I will do whatever I can to ensure a cooperative and orderly transition," Berman said in a concise concession statement early Wednesday.

In a similar high-profile mash-up between Democrats, Rep. Janice Hahn of San Pedro was cruising to an easy win against Rep. Laura Richardson of Long Beach in a newly drawn district that includes many minority, working-class communities, election results showed.

Among other closely watched races for California House seats, Assemblywoman Julia Brownley (D-Oak Park) narrowly defeated state Sen. Tony Strickland (R-Moorpark) in Ventura County, and Rep. Lois Capps (D-Santa Barbara) bested former Republican Lt. Gov. Abel Maldonado, according to results with all voter precincts reporting in those districts.

California's senior U.S. senator, Democrat Dianne Feinstein, won an easy reelection victory over nonprofit executive Elizabeth Emken, her underfunded, little-known Republican challenger.

The governor woke up Wednesday as one of the biggest apparent victors in Tuesday’s election, however.

Facing well-funded opposition, Brown campaigned heavily for Proposition 30 as a way to restore fiscal sanity to Sacramento and to stave off deep cuts to public schools and universities. The initiative calls for a quarter-cent increase to sales taxes for four years and a seven-year tax hike on California’s highest earners.

Californians have not approved a statewide tax increase since 2004.

Voters overwhelmingly rejected a competing measure bankrolled by millionaire civil rights lawyer Molly Munger -- Proposition 38 – which would have increased income taxes for most Californians to raise funds primarily for schools and early childhood education.

In one of the highest-profile state ballot measures, labor unions appeared to defeat Proposition 32, which would have reduced their political influence by barring unions from using paycheck deductions for political purposes.

Californians also soured on a measure to abolish the death penalty -– Proposition 34 -- which was trailing badly with most of the voter precincts reporting Wednesday morning.

Other law-and-order measures were greeting more warmly. Voters favored Proposition 36, which would change the three-strikes sentencing law so offenders whose third strikes were minor, nonviolent crimes could no longer be given 25 years to life in prison.

Voters also supported Proposition 35, which promoted increased punishment for sex trafficking of a minor. Both led by wide margins with most ballots counted.

With most ballots tallied across California, initiatives to label genetically engineered foods and change state law to create a new car insurance discount appeared headed for defeat.

One of the biggest surprises of the election was the Democrats' strong showing in legislative races. Democrats appear on the verge of winning a two-thirds majority in the state Senate and Assembly, enough to approve tax measures without Republican support.

In Los Angeles County, veteran prosecutor Jackie Lacey became the county's first female and first African American district attorney after defeating Deputy Dist. Atty. Alan Jackson. Jackson conceded early Wednesday morning.

Lacey, 55, touted herself as the only candidate with the experience to run the office. She had the support of her boss, Dist. Atty. Steve Cooley, who is retiring after three terms.

Los Angeles County voters also approved a local measure requiring adult film actors to wear condoms. With most precincts reporting, a measure to fund transportation projects by extending a countywide sales-tax increase for an additional 30 years remained just shy of the two-thirds vote required for approval.

Some races remained too close to call, including the San Diego congressional race between Rep. Brian P. Bilbray (R-Carlsbad) and Democrat Scott Peters, a San Diego environmental attorney. In the Coachella Valley, Democratic emergency room doctor Raul Ruiz was leading Rep. Mary Bono Mack (R-Palm Springs) with just under two-thirds of precincts reporting early Wednesday morning.

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SparkTruck's Surprise Lesson: Using Design Skills to Build Kids' Character

When Eugene Korsunskiy and seven of his fellow students from Stanford University’s d.school set out to tour the nation in a brightly painted truck full of laser cutters and rapid prototyping machines, they thought they were bringing a chance to play with high-tech maker tools to school kids who hadn’t had one yet.

And they were: SparkTruck, the educational make-mobile, made 73 stops this summer, treating 2,679 elementary and middle school students to hands-on workshops covering the basics of electrical engineering and digital fabrication, and giving a chance to make cool stuff in the process, like small robotic creatures and laser-cut rubber stamps.

But as the summer progressed, the SparkTruck team learned an unlikely lesson. The most rewarding part of the trip wasn’t introducing the kids to new technologies. Instead it was something far more basic: watching them struggle with design problems.

Only one of the SparkTruck team had training in education. But when the group planned its workshops, Korsunskiy explained, they knew they wanted to emphasize the same skills and processes they’d learned in design school. “Somewhere in each activity, we wanted the kids to get stuck, physically or mentally,” he said.

The point wasn’t to torture children, but to force them to work through an open-ended problem on their own.

Some teachers were skeptical. “One teacher told us, ‘My students are so conditioned to thinking that I’ll give them the right answers,’” Korsunskiy said. She didn’t think the group’s approach, which Korsunskiy summarized as “giving [kids] the space but not giving them the answers,” would work.

Sure enough, the SparkTruck team noticed kids’ resistance. Presented with a design problem, students would get stuck — and as the teacher predicted, they would come to the facilitators and ask, ‘How do I do this?’ They would beg, plead, and get frustrated. The SparkTruck team would withhold answers, instead asking a kid with, for example, no idea how to keep her robot from falling over, ‘How do you think it cold be done?’

Eventually, the hard-nosed approach paid off. “After an interaction like that, you see a gear shift in [a kid's] head,” said Korsunskiy. “Once you make it clear that you’re not there to provide the answer, they completely rise to the challenge.”

Unwittingly, the team had stumbled into a big problem — and a gathering cultural debate. According to social scientists (and the journalists who popularize their work), American children are said to be weenies, much more helpless and less resourceful than their age-matched peers in other countries. In educational settings, American kids are worryingly lacking in the faculty known as “grit,” the one that allows people to power through difficult problems, absorbing and learning from setbacks rather than giving up.

The point isn’t that young Americans are destined to be this way, but that somehow, amid all our prosperity, we’ve stopped giving kids the conditions they need to become self-sufficient.

Could hands-on, design-inspired education help? Korsunskiy and his team think so. Design lessons, Korsunisky noted, are based around creative problem-solving. They’re not about memorizing right answers but about developing critical thinking skills, learning to work through problems in a repeated process of brainstorming, testing solutions, and going back to the drawing board. In short, this kind of education builds the very skills of perseverance and intellectual independence that parents, teachers, and social critics say that American children have in short supply.

For Korsunskiy, watching students hit a wall — and then figure out a way over (or around) it — was the most rewarding part of the SparkTruck experience.

Students of today aren’t necessarily going to need to know how to operate, say, a CNC router, he noted. But if this generation is to succeed, it will absolutely need to know “how to approach hairy, multi-variate problems without freaking out” — he name-checked climate change and the obesity epidemic — i.e., to be able to leverage the skills and mindset that a shop-class environment can instill.

As the summer went on, the SparkTruck team shifted focus, beginning to feel more like emissaries for that problem-solving mindset and design process, rather than for the bright, shiny machines in the back.

Which isn’t to say that the machines aren’t helpful for grabbing the attention of students — and educators too.

“When we say we have laser cutters and 3-D printers on board, that makes it way more exciting to principals and teachers,” Korsunskiy said. “We sneak the thing about creativity in the back door.”

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CBS’s ‘Elementary’ gets prized post-Super Bowl slot

LOS ANGELES (TheWrap.com) – CBS’s freshman Sherlock Holmes drama “Elementary” will get a big boost in February, when it airs following Super Bowl XLVII, the network said Monday.

The series, which stars Jonny Lee Miller and Lucy Liu, delivers a modern-day take on the Sherlock Holmes saga, with both the detective and his sidekick Watson living in contemporary New York.

The special episode will air Sunday, February 3 at 10 p.m. ET/7 p.m. PT, following the network’s post-game coverage.

The series, which also stars Aidan Quinn, has already proven to be a hit for the network, regularly winning its Thursday at 10 p.m. timeslot. “Elementary,” which premiered September 27, has averaged a 3.5 rating/10 share in the advertiser-cherished 18-49 demographic, and 14.2 million total viewers.

Even so, the exposure that a post-Super Bowl slot provides certainly can’t hurt. The second-season premiere of NBC‘s “The Voice” after the Super Bowl, meanwhile, scored the highest ratings of any entertainment telecast since 2006.

“The Voice” scored a 16.3 rating in the key demo and 37.6 million total viewers overall. It was the best rating since a 16.5 for “Grey’s Anatomy” after the Super Bowl on ABC in 2006, and provided a welcome boost for fourth-place network NBC. The show was up 47 percent in the demo and 40 percent in total viewers over the episode of “Glee” that aired after the Super Bowl on Fox last year. (“Glee” scored an 11.1 and 26.8 million total viewers.)

The ratings victory gave “The Voice” a huge start to its second season. It spent much of 2011-12 neck-in-neck with the Wednesday night edition of “American Idol” to be the highest-rated show on television after “Sunday Night Football.” “Idol” ultimately beat “The Voice” on Wednesdays, but just barely.

The Super Bowl is typically the most-watched program of the year, and this year’s game set a record as the most-watched television program in U.S. history, with 111.3 million total viewers.

TV News Headlines – Yahoo! News

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Alarm Over India’s Dengue Fever Epidemic

Enrico Fabian for The New York Times

A man at the Yamuna River, an ideal breeding ground for mosquitoes. Filthy standing water abounds in New Delhi. More Photos »

NEW DELHI — An epidemic of dengue fever in India is fostering a growing sense of alarm even as government officials here have publicly refused to acknowledge the scope of a problem that experts say is threatening hundreds of millions of people, not just in India but around the world.

India has become the focal point for a mosquito-borne plague that is sweeping the globe. Reported in just a handful of countries in the 1950s, dengue (pronounced DEN-gay) is now endemic in half the world’s nations.

“The global dengue problem is far worse than most people know, and it keeps getting worse,” said Dr. Raman Velayudhan, the World Health Organization’s lead dengue coordinator.

The tropical disease, though life-threatening for a tiny fraction of those infected, can be extremely painful. Growing numbers of Western tourists are returning from warm-weather vacations with the disease, which has reached the shores of the United States and Europe. Last month, health officials in Miami announced a case of locally acquired dengue infection.

Here in India’s capital, where areas of standing water contribute to the epidemic’s growth, hospitals are overrun and feverish patients are sharing beds and languishing in hallways. At Kalawati Saran Hospital, a pediatric facility, a large crowd of relatives lay on mats and blankets under the shade of a huge banyan tree outside the hospital entrance recently.

Among them was Neelam, who said her two grandchildren were deathly ill inside. Eight-year-old Sneha got the disease first, followed by Tanya, 7, she said. The girls’ parents treated them at home but then Sneha’s temperature rose to 104 degrees, a rash spread across her legs and shoulders, and her pain grew unbearable.

“Sneha has been given five liters of blood,” said Neelam, who has one name. “It is terrible.”

Officials say that 30,002 people in India had been sickened with dengue fever through October, a 59 percent jump from the 18,860 recorded for all of 2011. But the real number of Indians who get dengue fever annually is in the millions, several experts said.

“I’d conservatively estimate that there are 37 million dengue infections occurring every year in India, and maybe 227,500 hospitalizations,” said Dr. Scott Halstead, a tropical disease expert focused on dengue research.

A senior Indian government health official, who agreed to speak about the matter only on the condition of anonymity, acknowledged that official figures represent a mere sliver of dengue’s actual toll. The government only counts cases of dengue that come from public hospitals and that have been confirmed by laboratories, the official said. Such a census, “which was deliberated at the highest levels,” is a small subset that is nonetheless informative and comparable from one year to the next, he said.

“There is no denying that the actual number of cases would be much, much higher,” the official said. “Our interest has not been to arrive at an exact figure.”

The problem with that policy, said Dr. Manish Kakkar, a specialist at the Public Health Foundation of India, is that India’s “massive underreporting of cases” has contributed to the disease’s spread. Experts from around the world said that India’s failure to construct an adequate dengue surveillance system has impeded awareness of the illness’s vast reach, discouraged efforts to clean up the sources of the disease and slowed the search for a vaccine.

“When you look at the number of reported cases India has, it’s a joke,” said Dr. Harold S. Margolis, chief of the dengue branch at the Centers for Disease Control and Prevention in Atlanta.

Neighboring Sri Lanka, for instance, reported nearly three times as many dengue cases as India through August, according to the World Health Organization, even though India’s population is 60 times larger.

Hari Kumar contributed reporting.

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Fiscal Impasse Leads to Caution After Election

Business leaders and investors on Wall Street reacted cautiously to President Obama’s re-election early Wednesday, warning that the focus would quickly shift from electoral politics to the looming fiscal uncertainty in Washington.

Stocks opened sharply lower in New York, with the Standard & Poor’s 500-stock index down 1.4 percent, while European shares drifted lower and Asian stocks were mixed. While many executives on Wall Street and in other industries favored Mitt Romney, most had already factored in the likelihood of Mr. Obama winning a second term.

“The bottom line is that this looks like a status quo election,” said Dean Maki, chief United States economist at Barclays. “The problem with that is that it doesn’t resolve some of the main sources of uncertainty that are hanging over the economy.”

Companies in some sectors, like hospitals and technology, could see a short-term pop, said Tobias Levkovich, chief United States equity strategist with Citi. Other areas, like financial services as well as coal and mining, could be hurt as investors contemplate a tougher regulatory environment.

Mr. Levkovich predicted that the market would remain volatile between now and mid-January. If Congress and the president cannot come up with a plan to cut the deficit, hundreds of billions in Bush-era tax cuts are set to expire at the beginning of 2013 while automatic spending cuts will sharply cut the defense budget and other programs.

Known as the fiscal cliff, this simultaneous combination of dramatic reductions in government spending and tax increases could push the economy into recession in 2013, economists fear.

In early trading, the Euro Stoxx 50 index, a barometer of euro zone blue chips, fell 1 percent, while the FTSE 100 index in London was 0.4 percent lower.

The S.&P./ASX 200 in Australia closed up 0.7 percent, as did the Hang Seng Index in Hong Kong. The Nikkei 225 stock average in Japan ended trading little changed.

“There’s a huge question mark hanging over what happens in the next few weeks,” said Aric Newhouse, senior vice-president of policy and government relations at the National Association of Manufacturers. “The fiscal cliff is the 800-pound gorilla out there.”

“We can’t wait,” he said. “We think the idea of going over the cliff has to be taken off the table. We’ve got to get to the middle ground.”

For all the anticipation, some observers said the election still left plenty of unanswered questions.

“While we have clarity on the players now, we don’t have any more clarity on what will happen in terms of the fiscal cliff,” Mr. Maki said. “We still have a divided government and they haven’t been able to agree on what to do.”

If the full package of tax increases and spending cuts go into effect, that would equal a $650 billion blow to the economy, Mr. Maki said, equivalent to 4 percent of the gross domestic product.

Mr. Maki envisions a partial compromise, with $200 billion in tax increases and spending cuts. Partly because of that, he estimates, the annual rate of economic growth will dip to 1.5 percent in the first quarter of 2013 from 2.5 percent in the fourth quarter. He predicted that if the full fiscal cliff were to hit, the economy would contract in the first half of 2013.

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Mothers from Central America search for missing kin in Mexico

SALTILLO, Mexico — The mothers knock on the doors of flophouses and morgues. They sift through pictures of prisoners and the dead. Clutching pictures of their own, some from long ago, they ask the same questions, over and over.

Have you seen him? Does she look familiar?

Occasionally, there is a reported sighting. More often, it's another shake of the head, a "Sorry, no." And with that, weariness stooping their shoulders and worry sagging their faces, they board their bus and move on to another town.

By last weekend, these mothers, wives and sisters of missing Central American migrants had already crossed some of Mexico's most dangerous territory in their two-bus caravan.

Following a route often used by migrants northward along the Gulf Coast to the U.S., they had entered the country in the south through Tabasco state. They traveled through Veracruz and Tamaulipas, sites recently of horrific massacres of Central Americans and others, stopping along the way to ask and search — against all the odds wishing for a happy ending.

By the time they finish what has become an annual mission organized by several migrant rights and church groups, they will have traveled to 23 cities and towns in 14 states in 19 days. A total of nearly 3,000 miles.

Aboard the buses, with the lived-in feel of ordered chaos, the women pass the time dozing, chatting, occasionally watching a movie.

Despite their pain, or perhaps because of it, they find friendship. The Nicaraguans share stories of their experiences during their country's civil war, telling of relatives killed or forced into armies; the Hondurans recount tales of their nation's utter, violent poverty that fuels one of the world's highest homicide rates and drives their children to seek lives elsewhere.

Emotions soar and fall. The women joke and tease one another and laugh. Then, suddenly, one remembers the son she is missing and breaks into sobs and another moves to her side to comfort her.

Another nine hours through hot, dusty cactus fields brought them here to Saltillo, the capital of Coahuila state, where the top leader of the notorious Zetas paramilitary cartel was slain by government forces last month. By all accounts, it is the Zetas who most routinely and viciously prey on the migrants, thousands of whom have gone missing in recent years — kidnapped, killed, pressed into involuntary labor by drug traffickers, or simply lost to poverty and desperation.

Dilma Pilar Escobar last heard from her daughter, Olga, in January 2010. Olga had taken off from their home in Progreso, Honduras, leaving behind five children, with the plan of reaching the United States. Like so many others, her idea was to earn a little money, make things a little easier for her mother and her children.

Now Escobar is raising her grandchildren, listening to their questions every night about when their mother might come home. She is running out of answers.

"I've looked in hospitals, in morgues," said Escobar, 55. "We see so much about what's happening in Mexico on TV. It puts a lot in your head."

Escobar was inspired to make the trip in part by a local radio program that attempts to help families with missing relatives.

"It gave me the push to come here," said the woman with dark, unsmiling eyes, grasping an 8-by-10 photo of Olga that hangs from her neck on a green cord.

In each city or town, the mothers stage a public event to make their presence known. A Mass. A march. Here in Saltillo, they converged on the downtown Plaza de Armas, the pale-blue-and-white that adorns all Central American flags fluttering in the breeze ahead of the slow march of mothers. They hung their photos of loved ones on clotheslines at the center of the square.

The women — about 40 on this year's caravan — sleep on cots in churches or in "migrant houses," shelters set up by a number of communities, where they also receive donated meals.

"We are facing a humanitarian tragedy," Tomas Gonzalez, a Franciscan friar who runs a shelter in Tabasco, told the women. "Mexico has become a cemetery for migrants."

In August 2010, 72 migrants from El Salvador, Honduras, Guatemala and a handful of other countries were slain execution-style, hands tied behind backs, shot once in the head, in Tamaulipas state, which borders Texas. Among the youngest was 15-year-old Yedmi Victoria Castro of El Salvador. The Zetas were presumed responsible. Dozens more bodies were found in the same region in the months that followed.

Not a week goes by, it seems, without fresh reports of hidden graves and unidentified dead. But the Mexican government has been slow to recognize the epidemic of missing persons, only this year moving to toughen legislation and expand the collection of DNA samples and other data.

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Simon Cowell Stamps His Sound on Sony's Top End

The concept of “personal music” has become so embedded in modern culture that we no longer even entertain the idea of not pocketing our music and piping it directly into our brains.

For those of us minted prior to the iPod age, the Sony brand is synonymous with creating and laying that foundation with its Walkman line of portable players. Clearly, much has changed since the early ’80s, and Sony has been leapfrogged by many competitors in portable music. But that doesn’t mean the big “S” doesn’t know a good thing when it hears it. That’s why the company has teamed up with British mega-producer and singing-show lightning rod Simon Cowell to develop the MDR-X10, a premium on-the-ear headphone.

The industrial design of these “X Factor” headphones, all matte and polished silver polycarbonate, is thoughtful and aesthetically pleasing. However, the ear pads on the X10 are rather deceiving — they’re not hollowed out like most bigger cans on the market. Instead, they’re flat, but when placed over your head, the cushy memory foam envelopes your ear without significantly altering the sound-channeling shape of the ear’s cartilage. This design creates an excellent acoustic seal that markedly diminishes the incursion of outside ambient sound. Another pleasing design element is the removable, single-sided flat cable that comes in two flavors — one is a plain straight cable with a mini phone jack, and the other is an iGadget-friendly cable with an in-line mic/remote assembly.

The X10s are tuned to accentuate the predominant sounds in popular music. And straight out of the box, the proprietary 50-millimeter driver pumps the bass and treble just the way you’d expect. That initial listen demonstrated to me how headphones with boosted bass often overshadow the subtleties of the midrange elements.

However, to get the truest impression of a speaker’s sound, whether it’s inside a headphone or a big wooden enclosure, they need to be “burned in” for 100 hours or so. It’s a simple process: Just connect them to your audio source, turn the music up to about six on the dial, and walk away for four days.

That’s exactly what I did. When I returned to Cowell’s cans, they were greatly improved. The midrange frequencies in the soundstage were much more defined. The bass and treble were still holding court, but the mids were definitely clearer and made space for themselves in my ears. The post-burn-in sound was deep, rich, full and well defined — much more balanced overall, and closer to what I’d expect from a set of headphones that costs $300.

Simon Cowell’s personality on television is definitely polarizing, but his success at discovering and launching musical talent is well documented. Sony’s development partnership with the notoriously nit-picky producer has actually served this product well.

Andrew Sivori, Sony’s VP of personal audio, tells me Cowell was involved in the development of the headphone’s sound signature throughout the entire process.

“He gave fantastic feedback,” Sivori says. “He listens for a living, and he’s been incredibly successful at it.”

It looks like Sony and Cowell may have another hit on their hands. The X10s are comfortable, they kick out some great sound, and they look great doing it.

WIRED Ear pads are plush and comfy. Deep, rich, dynamic sound. Comes with two replaceable flat cords and a 1/4-inch plug for an audiophile sound system. They fold up for portability. High-quality protective case.

TIRED Price is steep. Headband could use a little more padding at the top of the head. Tough to simultaneously wear glasses.

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American composer Elliott Carter dies at age 103

(Reuters) – Classical composer Elliott Carter, who twice won Pulitzer Prizes in a career that spanned more than 75 years, died on Monday in New York at age 103, music publisher Boosey & Hawkes said.

Carter was awarded Pulitzer Prizes in 1960 and 1973 for string quartet compositions. He composed 158 works, including several at over 100 years of age. One composition for chamber orchestra is scheduled for a world premier in February.

“The great range and diversity of his music has, and will continue to have, influence on countless composers and performers worldwide,” the publisher said. “He will be missed by us all but remembered for his brilliance, his wit and his great canon of work.”

He was inducted into the American Classical Music Hall of Fame in 1998 and celebrated his 100th birthday at New York‘s Carnegie Hall in 2008 with a new work performed by the Boston Symphony Orchestra.

Carter was presented the National Medal of Arts, the highest award given to artists by the United States, in 1985. He also received national honors from Germany and France.

(Reporting by David Bailey; Editing by Cynthia Johnston and Mohammad Zargham)

Music News Headlines – Yahoo! News

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New Drugs for Lipids Set Off Race

LOS ANGELES — A new class of powerful cholesterol-reducing drugs is showing promising results, potentially offering a new option for people who do not respond to medication now on the market, according to studies presented at a conference of heart specialists here on Monday.

Although the final word on the effectiveness of the drugs is still a few years away, the results so far are so promising that pharmaceutical companies are racing to bring them to market.

In early- and middle-stage trials, use of the experimental drugs reduced so-called bad cholesterol by about 40 to 70 percent in a matter of weeks, equivalent to the reduction achieved by the most effective statins like Lipitor. But it appears that the new drugs can be used along with statins, lowering cholesterol even further.

“With these drugs, together with statins, you can get virtually everyone to the goal,” Dr. Frederick Raal of the University of the Witwatersrand, in Johannesburg, South Africa, who presented one of several studies on these new drugs at the American Heart Association’s scientific meeting here.

The most advanced of the drugs, which as a class are called PCSK9 inhibitors, is only now entering the final stages of clinical trials and is not likely to get to market until 2015 at the earliest.

And there are still some caveats. One is that while the drugs lower cholesterol, it has not yet been shown that they actually reduce the risk of heart attacks, strokes or other cardiovascular problems.

Furthermore, many of the studies so far have lasted no more than 12 weeks and involved fewer than 200 people. Far longer and larger studies are needed to show that the drugs would keep working over a lifetime and would be safe.

So far, however, the studies show “quite good safety,” Dr. Peter Wilson of Emory University said in a presentation here discussing the studies. “This is extremely promising.”

The drugs have to be injected, typically every two to four weeks. That means that the PCSK9 inhibitors are not likely to be widely used for “garden variety high cholesterol,” said Dr. Gordon Tomaselli, chief of cardiology at Johns Hopkins.

Still, millions of Americans cannot lower their cholesterol sufficiently using statins alone, providing a market that could reach billions of dollars in annual sales for a successful drug.

Leading the race so far is the team of Sanofi, the big French drug company, and Regeneron Pharmaceuticals, a biotechnology company in Tarrytown, N.Y.

The companies announced Monday that they were beginning a Phase 3 trial — usually the last step before filing for approval — involving 18,000 patients with a recent heart attack or worsening chest pain who cannot lower their cholesterol with statin therapy alone. The patients will inject themselves once every two weeks with either the drug or a placebo, while continuing to take statins.

The study, which will take at least two years, will determine whether the drug, known by the awkward code name SAR236553/REGN727, can reduce the rate of heart attacks, strokes and other cardiovascular problems.

In a midstage study published recently in The New England Journal of Medicine, patients who took the Sanofi drug plus a high dose of atorvastatin, the generic equivalent of Lipitor, had a mean 73 percent reduction in low-density lipoprotein cholesterol, the so-called bad cholesterol, compared with a 17 percent reduction for those taking only the high dose of the statin.

Amgen seems to be next in line, saying it plans to begin Phase 3 trials early next year. Pfizer and Roche have drugs in midstage clinical trials. Others in pursuit include Eli Lilly & Company and Alnylam.

Dr. Evan A. Stein of the Metabolic and Atherosclerosis Research Center in Cincinnati, said that about 10 to 20 percent of patients could not tolerate statins at all, or at least could not tolerate doses high enough to lower cholesterol sufficiently. Their main alternative now is Merck’s Zetia, which reduces cholesterol about 18 percent.

Dr. Stein, who is a consultant to Amgen, presented the results on Monday of a trial of Amgen’s drug, AMG 145, in such patients.

Patients receiving AMG 145 experienced an average reduction in LDL cholesterol after 12 weeks of 41 to 51 percent, depending on the dose. Those who received both AMG 145 and Zetia had an even greater average reduction — 63 percent. By contrast, those who received Zetia and a placebo had a drop in bad cholesterol of only 15 percent.

After 12 weeks, only 7 percent of the patients on Zetia alone reduced LDL to 100 milligrams per deciliter, which is the goal for many people. About 61 percent of those on the highest dose of AMG 145 did so, as did 90 percent on both AMG 145 and Zetia. The trial results were also published online by The Journal of the American Medical Association.

LDL cholesterol is removed from the blood when it binds to LDL receptors on the surface of liver cells, and then is taken inside the cells. PCSK9 — which stands for proprotein convertase subtilisin/kexin type 9 — also binds to the LDL receptor, and when it does so, the receptor is destroyed along with the LDL.

But if PCSK9 does not bind, the receptor can return to the surface of the cell and remove more cholesterol. The drugs, which in general are proteins known as monoclonal antibodies, block PCSK9 from binding to the receptor.

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Antwerp Journal: Antwerp’s Diamond Industry Facing Challenges

Colin Delfosse for The New York Times

Indian businessmen in the diamond district of Antwerp, Belgium.

ANTWERP, Belgium — Step off the train here and you cannot miss the signs on the stores: Diamond World, Diamond Gallery, Diamond Creations or simply, Diamonds. Of late, there are the banners and posters reading simply, “Antwerp Loves Diamonds.”

Though this Belgian port has had a love affair with diamonds for centuries, of late it seems to be losing some of its passion. For years now, much of the lucrative but labor-intensive business of cutting and polishing stones has been drifting to low-wage centers in the developing world, like Mumbai, Dubai and Shanghai.

More ominously, in recent years, diamond traders have been accused of a range of violations, including tax fraud, money laundering and cheating on customs payments when buying and selling stones.

Local business leaders recognize the threat. This year, they embarked on what local newspapers described as a “charm offensive.” In a 160-page program, titled Project 2020, the World Diamond Center, a trade-promotion group, outlined plans to draw business back to Antwerp by simplifying and accelerating trading via online systems. That, the industry hopes, will win back some of the polishing business lost to Asian countries with new technology, like fully automated diamond polishers, and generally burnish the image of the diamond business in the public’s jaded eye.

“This is our strength,” said Ari Epstein, 36, a lawyer who is chief executive of the World Diamond Center and the son of a diamond trader, whose father emigrated from a village in Romania in the 1960s. “We have the critical mass so that every diamond finds a buyer and seller.”

Antwerp has by no means fallen out of love with the gems. In all, the market employs 8,000 people and creates work indirectly for 26,000 others as insurers, bankers, security guards and drivers. Last year, turnover in the local diamond business amounted to $56 billion, Mr. Epstein said, its best year ever.

While total revenues are expected to drop this year because of the troubled world economy, he acknowledged, a stroll along Hoveniersstraat, or Gardner’s Street, leads through the heart of the market, where almost 85 percent of the world’s uncut diamonds are still traded.

“I come here once a month,” said Sheh Kamliss, a trader in his 30s, who travels from his native India to buy uncut stones and sell polished diamonds. “This is the international market,” he added, chatting with fellow Indian traders outside the Diamond Club of Antwerp, one of many locations where deals are struck.

On any given day but Friday or the Jewish holidays, Hoveniersstraat, with its tiny Sephardic synagogue, is liberally sprinkled with Orthodox Jewish traders, many of them Hasidim.

But their once dominant presence has been squeezed by the arrival of traders from new markets, like Mr. Kamliss. Now people from about 70 nations are present, including Indians, Israelis, Lebanese, Russians, Chinese and others. Along neighboring Lange Herentalsestraat, Rachel’s Kosher Restaurant is now flanked by the Bollywood Indian Restaurant and the Shanti Shop Indian supermarket. In the nearby Jewish quarter, Patel’s Cash & Carry recently installed itself right next to Moszkowitz, the butcher.

Some here say this globalization of the business has opened the door to abuse.

Omega Diamonds, a major market maker, came under investigation and its executives fled Belgium when an employee-turned-whistle-blower revealed in 2006 how Omega had traded diamonds out of Africa for years, avoiding taxes by transacting deals through Dubai, Tel Aviv and Geneva, then moving the profits back to Belgium.

“Because of global changes, the trade routes have changed,” said David Renous, 47, the whistle blower, who is now writing a book on the subject. “New hubs, like Dubai, the Singapore of the Middle East, sometimes close their eyes to criminality.”

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